| Lineups found Starting lineup changes since last game |
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| August 2010 |
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| Coach Benítez since 08-Jun-10 |
| October 2010 |
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 24-Aug to 16-Oct Thiago Motta right knee arthroscopy |
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| 15-Sep to 18-Sep Pandev right collateral ligament knee strain |
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 19-Sep to 19-Sep Zanetti taken to hospital following today game after chest pains |
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| 20-Sep to 20-Sep Nagatomo 2nd Yellow Card assigned by Lega Serie A Federal Committee |
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| 20-Sep to 05-Oct Zanetti post-traumatic pneumothorax |
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| 04-Oct to 19-Oct Córdoba, I left biceps femoris muscle strain |
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| 09-Oct to 22-Oct Cambiasso left biceps femoris muscle strain |
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| 09-Oct to 27-Oct Milito, D left biceps femoris muscle strain |
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| 13-Oct to 15-Nov Mariga left biceps femoris muscle strain |
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| 21-Oct to 08-Nov Kharja right thigh flexor muscle injury |
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| 21-Oct to 08-Nov Stanković right calf flexor muscle strain |
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| 27-Oct to 26-Nov Thiago Motta right knee pain |
| November 2010 |
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| 30-Oct to 10-Nov Júlio César, Soares right thigh strain |
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| 30-Oct to 11-Nov Cambiasso left thigh strain |
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| 03-Nov to 25-Nov Muntari right calf |
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| 07-Nov to 25-Apr Samuel right anterior cruciate and outer collateral ligaments torn |
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| 07-Nov to 26-Nov Maicon left thigh strain |
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 25-Nov to 06-Dec Eto'o Federal Judge Ban for violent behaviour (2 of 3 matches) |
| December 2010 |
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| January 2011 |
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| Coach Leonardo since 24-Dec-10 |
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| 19-Dec to 31-Jan Sneijder left leg biceps femoris muscle strain |
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| 27-Dec to 27-Dec Ranocchia joining Inter Milan on January 1st |
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| 01-Jan to 31-Jan Nagatomo representing Japan in 2011 AFC Asian Cup in Qatar |
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| 05-Jan to 07-Jan Eto'o Federal Judge Ban for violent behaviour (3rd of 3 matches) |
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| 05-Jan to 28-Jan Júlio César, Soares left leg biceps femoris muscle strain |
| M.5 | 12-Jan | | Genoa | | 3-2 | 4-3-1-2 | |
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| M.6 | 26-Jan | away | Napoli | | 0-0 | 4-3-1-2 | In:Córdoba, Chivu, T Motta, Stankov., Out:Materaz., Santon, Mariga, Muntari, |
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| 27-Jan to 04-Feb Córdoba, I right shoulder injury |
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| 27-Jan to 14-Feb Stanković right thigh semimembranosus muscle strain |
| April 2011 |
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| 28-Jan to 30-Jan Chivu 4th yellow card ban (1 match) |
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| 28-Jan to 30-Jan Córdoba, I 4th yellow card ban (1 match) |
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| 28-Jan to 30-Jan Stanković 4th yellow card ban (1 match) |
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| 28-Jan to 14-Feb Mariga right leg biceps femoris muscle strain |
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| 31-Jan to 31-Jan Nagatomo joins Inter Milan (loan) |
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| 31-Jan to 17-Feb Lúcio right thigh adductor muscle strain |
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| 04-Feb to 20-Feb Chivu Federal Judge ban for violent conduct (4 matches) |
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| 07-Feb to 20-Mar Milito, D left thigh biceps femoris muscle strain |
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| 14-Feb to 16-Feb Thiago Motta 4th yellow card ban (1 match) |
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| 17-Feb to 23-Feb Sneijder right adductor muscle fatigue |
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| 25-Feb to 28-Feb Maicon 4th yellow card ban (1 match) |
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| 25-Feb to 14-Mar Cambiasso left thigh adductor muscle strain |
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| 14-Mar to 16-Mar Zanetti flu |
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| 18-Mar to 20-Mar Córdoba, I red card ban (1 match) |
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| 01-Apr to 03-Apr Lúcio 4th yellow card ban (1 match) |
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| 04-Apr to 06-Apr Lúcio Champions League yellow card ban (1 match) |
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| 08-Apr to 10-Apr Chivu red card ban (1 match) |
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| 11-Apr to 13-Apr Chivu Champions League red card ban (1 match) |
| M.7 | 19-Apr | away | Roma | | 0-1 | 4-3-1-2 | In:J César, Lúcio, Nagatomo, Sneijder, Milito, Out:Castell., Córdoba, Chivu, T Motta, Eto'o, |
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| May 2011 |
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| 21-Apr to 28-Apr Thiago Motta left hip pain |
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| 26-Apr to 17-May Stanković left adductor muscle strain |
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| 29-Apr to 02-May Júlio César, Soares red card ban (1 match) |
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| 30-Apr to 10-May Sneijder calf |
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| 06-May to 09-May Mariga 4th yellow card ban (1 match) |
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| 09-May to 11-May Ranocchia Coppa Italia yellow card ban (1 match) |
| M.8 | 11-May | | Roma | | 1-1 | 4-3-1-2 | In:Chivu, Mariga, Kharja, Pazzini, Eto'o, Out:Ranocch., Stankov., Sneijder, Pandev, Milito, |
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| 12-May to 12-May Zanetti 1000th match (Talleres33 Banfield66 Inter749 Argentina152) |
| M.9 | 29-May | away | Palermo | | 1-3 | 4-3-1-2 | In:Ranocch., T Motta, Stankov., Sneijder, Out:Maicon, Cambias., Mariga, Kharja, |
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| Color References: GK, DF, DM, MF, FW , Unknown Pos |