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| 12-Apr-22 18:15
Estadio General Pablo Rojas
Ref: Tobar
Lm 1: Schiemann
Lm 2: Ríos, C
|
 | Cerro Porteño 
Romero, Fernando 41'
Romero, Fernando 46' 
Espínola, Alberto 70'
| 3 - 1 |  Colón de Santa Fe
31' Meza, Eric
|
| |
| 12-Apr-22 18:15
San Carlos de Apoquindo
Ref: González, L
Lm 1: Nievas, A
Lm 2: Berisso
|
 | Universidad Católica
Núñez, Marcelino 45'
Zampedri 92' 
| 2 - 1 |  Sporting Cristal
73' Loyola, N
|
| |
| 12-Apr-22 19:15
Bombonera
Ref: Tejera, G
Lm 1: Taran
Lm 2: Soppi
|
 | Boca Juniors
Benedetto 25'
Benedetto 96'
| 2 - 0 |  Always Ready
|
| |
| 12-Apr-22 21:30
Estadio Campeón del Siglo
Ref: Claus
Lm 1: Boschilia
Lm 2: Back
|
 | Peñarol
Ramos, JM 45'
Carrizo, F 49'
| 2 - 1 | Olimpia
80' González, Walter (1995)
|
| |
| 12-Apr-22 21:30
Estádio do Maracanã
Ref: Valenzuela
Lm 1: Torrealba, L
Lm 2: Ponte
|
 | Flamengo
Gabi, Barbosa 11'
Everton Ribeiro 26'
Everton Ribeiro 60'
| 3 - 1 | Talleres de Cordoba
45' Fértoli
|
| |
| 12-Apr-22 21:30
Allianz Parque
Ref: López, D
Lm 1: Cardozo
Lm 2: Aranda
|
 | Palmeiras
Zé Rafael 41'
Rafael Navarro 46'
Rafael Navarro 53'
Rafael Navarro 56'
Rafael Navarro 77'
Rony, dSB 79'
Raphael Veiga 86'
Raphael Veiga 90' 
| 8 - 1 | Independiente Petrolero
5' Correa, Erick
 42' Rioja, J
|
| |
| 13-Apr-22 18:00
Estadio Defensores del Chaco
Ref: Tello
Lm 1: Chade
Lm 2: Milone
|
 | Libertad
Cardozo, O 3'
Melgarejo 34'
| 2 - 1 | Caracas
20' Osei, KB
|
| |
| 13-Apr-22 18:00
Monumental David Arellano
Ref: Ostojich
Lm 1: Berisso
Lm 2: Nievas, A
|
 | Colo Colo
Lucero, JM (1991) 27'
Pavez, E 56'
| 2 - 1 | Alianza Lima
69' Benítez, E
|
| |
| 13-Apr-22 21:00
Monumental
Ref: Matonte
Lm 1: Soppi
Lm 2: Taran
|
 | River Plate
Fernández, Enzo 10'
de la Cruz, Nicolás 33'
Zuculini, B 95'
| 2 - 0 | Fortaleza
|
| |
| 13-Apr-22 21:00
Mineirão
Ref: Loustau, P
Lm 1: Brailovski
Lm 2: Raineri
|
 | Atlético Mineiro
Ademir, Fumacinha 85'
| 1 - 1 | América-MG
51' Felipe Azevedo
|
| |
| 13-Apr-22 21:00
Arena Corinthians
Ref: Aquino, E
Lm 1: Cardozo
Lm 2: Aranda
|
 | Corinthians
Caldera 4'  og
João Victor, Marcelino 57'
| 1 - 0 |  Deportivo Cali
|
| |
| 13-Apr-22 21:00
Parque Central
Ref: Roldán
Lm 1: Guzmán, A
Lm 2: Ortiz, R
|
 | Nacional
Carballo, F 31' 
| 0 - 0 | Estudiantes de La Plata
31' Andújar
|
| |
| 13-Apr-22 21:00
Estadio Banco Guayaquil
Ref: Ortega, K
Lm 1: Orué
Lm 2: Alarcón
|
 | Independiente del Valle 
Sornoza 52'
Sornoza 89'
| 2 - 2 | Deportes Tolima
15' Lucumí
41' Plata, A
|
| |
| 14-Apr-22 19:00
Arena da Baixada
Ref: Herrera
Lm 1: Belatti
Lm 2: de Almeida
|
 | Atlético Paranaense
Terans 65'
| 1 - 0 | The Strongest
|
| |
| 14-Apr-22 21:00
Jose Amalfitani
Ref: Ospina, A
Lm 1: Vela
Lm 2: Ruiz, D
|
 | Velez Sarsfield
De los Santos, M 8'
Natan, Bernardo 47' og
| 2 - 2 | Red Bull Bragantino
2' Ytalo
62' Ytalo
|
| |
| 14-Apr-22 21:00
George Capwell
Ref: Hinestroza
Lm 1: Navarro
Lm 2: Fuentes, D
|
 | Emelec
Rojas, Joao (1997) 11'
| 1 - 1 | Deportivo Táchira
4' Chacón, Yerson
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