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| 03-May-22 17:15
Estadio Hernando Siles
Ref: Menéndez
Lm 1: Orué
Lm 2: Sánchez, J
|
 | The Strongest 
Triverio 32' 
Triverio 51'
Prost, Martín 70'
Cascini, J 91'
Erick, Conrado 94'  og
| 5 - 0 |  Atlético Paranaense
|
| |
| 03-May-22 17:15
Olímpico Ciudad Universitaria
Ref: Matonte
Lm 1: Soppi
Lm 2: Fernández, S
|
 | Caracas 
Akinyoola 51'
| 1 - 0 |  Libertad
|
| |
| 03-May-22 17:15
Polideportivo de Pueblo Nuevo
Ref: Echavarría
Lm 1: Belatti
Lm 2: de Almeida
|
 | Deportivo Táchira
Uribe, A 37'
| 1 - 4 |  Emelec
3' Rodríguez, Sebastián (1992)
 11' Rodríguez, Sebastián (1992)
 59' Rodríguez, Sebastián (1992)
74' Cabeza
|
| |
| 03-May-22 19:30
Olímpico Patria
Ref: Lamolina, N
Lm 1: Del Yesso
Lm 2: Milone
|
 | Independiente Petrolero
| 0 - 5 | Palmeiras
17' Raphael Veiga
22' Raphael Veiga
60' Raphael Veiga
62' Rafael Navarro
74' Murilo Cerqueira
|
| |
| 03-May-22 21:30
Jorge Luis Hirschi
Ref: Roldán
Lm 1: Guzmán, A
Lm 2: Navarro
|
 | Estudiantes de La Plata
Castro, Manuel 41'
| 1 - 0 | Nacional
|
| |
| 03-May-22 21:30
Estádio Independência
Ref: Herrera
Lm 1: Navarro
Lm 2: González, P
|
 | América-MG
Conti, Germán 39'
| 1 - 2 | Atlético Mineiro
13' Guilherme Arana
37' Nacho Fernández
|
| |
| 04-May-22 19:00
Estadio Mario Alberto Kempes
Ref: Aquino, E
Lm 1: Saldivar, M
Lm 2: Cañete
|
 | Talleres de Cordoba
Willian Arão 34' og
Santos, Michael 57'
| 2 - 2 | Flamengo
50' de Arrascaeta
69' Pedro, AdS
|
| |
| 04-May-22 19:00
Brig Gral Estanislao Lopez
Ref: Claus
Lm 1: Pires
Lm 2: Gil
|
 | Colón de Santa Fe
Farías, Facundo 21'
Bernardi, Cr 69'
| 2 - 1 | Cerro Porteño
73' Marcelo Moreno
|
| |
| 04-May-22 19:00
Estadio Deportivo Cali
Ref: Cunha
Lm 1: Nievas, A
Lm 2: Llarena
|
 | Deportivo Cali
Gutiérrez, Teo 67' 
| 0 - 0 | Corinthians
 67' Cássio
84' Fábio Santos, (1985)
|
| |
| 04-May-22 20:00
Estadio Hernando Siles
Ref: Ortega, K
Lm 1: Orué
Lm 2: Sánchez, J
|
 | Always Ready
| 0 - 1 | Boca Juniors
37' Salvio
|
| |
| 04-May-22 20:00
Estadio Defensores del Chaco
Ref: Daronco
Lm 1: Manis
Lm 2: da Silva Alves
|
 | Olimpia
Salcedo, Saúl 33'
| 1 - 0 | Peñarol
|
| |
| 04-May-22 21:00
Manuel Murillo Toro
Ref: Loustau, P
Lm 1: Chade
Lm 2: Savorani
|
 | Deportes Tolima
Ibargüen, A 88'
| 1 - 0 | Independiente del Valle
|
| |
| 04-May-22 21:00
Estadio Nacional de Lima
Ref: Rojas, A
Lm 1: Vela
Lm 2: Gallego
|
 | Sporting Cristal
Liza 43'
| 1 - 1 |  Universidad Católica
77' Zampedri
|
| |
| 05-May-22 19:00
Placido Aderaldo Castelo
Ref: Ostojich
Lm 1: Taran
Lm 2: Barreiro
|
 | Fortaleza
Romero, Silvio 4'
Matheus Jussa 7'
| 1 - 1 | River Plate
17' Fernández, Enzo
|
| |
| 05-May-22 21:00
Estadio Nacional de Lima
Ref: Gallo, N
Lm 1: Ortiz, R
Lm 2: Fuentes, D
|
 | Alianza Lima
Aguirre, W 46'
| 1 - 1 | Colo Colo
22' Lucero, JM (1991)
27' Lucero, JM (1991)
|
| |
| 05-May-22 21:00
Nabi Abi Chedid
Ref: Ospina, A
Lm 1: Ruiz, D
Lm 2: León, A
|
 | Red Bull Bragantino
Hurtado, José (2001) 84'
| 1 - 1 | Velez Sarsfield
14' Pratto
|
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