| | | | | |
| 01-Mar-22 18:15
Monumental
Ref: Vargas
Lm 1: Tapia
Lm 2: Flores, R
|
 | Monagas 
González, Oscar (1992) 46'
| 1 - 0 |  Everton
|
| |
| 01-Mar-22 20:30
Estadio Hernando Siles
Ref: Ospina, A
Lm 1: Ruiz, D
Lm 2: Roldán
|
 | The Strongest
Amaral, R 1'
Prost, Martín 5'
Prost, Martín 58'
| 3 - 0 |  Plaza Colonia
|
| |
| 01-Mar-22 21:30
São Januário
Ref: Rapallini
Lm 1: Belatti
Lm 2: Bonfá
|
 | Fluminense 
Willian, Siqueira 61'
Arias, Jhon 72'
| 2 - 0 | Millonarios
|
| |
| 02-Mar-22 17:15
Olimpico Atahualpa
Ref: Claus
Lm 1: Manis
Lm 2: Alves de Souza
|
 | Universidad Católica Ecuador 
Zamora, SG 10'
Díaz, I 35' 
| 2 - 0 | Bolivar
|
| |
| 02-Mar-22 19:15
Estadio Defensores del Chaco
Ref: Tello
Lm 1: Rodríguez, F
Lm 2: Del Yesso
|
 | Guaraní 
Fernández, Fernando 13' 
Cáceres, Marcos 15'
Ayala, W 99' 
Ortíz, W 99'
Benítez, Ángel 99'
Bareiro, S 99'
Vásquez, DS 99' 
Ferreira, Rodi 99'
Fernández, Roberto (2000) 99'
| 2 - 3
(4) : (5) | América-MG
59' Wellington Paulista
74' Wellington Paulista
 og 92' Vásquez, DS
99' Wellington Paulista
99' Iago Maidana
99' Henrique Almeida
99' Ramírez, Juan (1997)
99' Rodolfo Bardella
99' Patric
99' Everaldo, SdN
|
| |
| 02-Mar-22 19:30
Estadio Nacional de Lima
Atte:38000
Ref: Matonte
Lm 1: Soppi
Lm 2: Barreiro
|
 | Universitario de Deportes 
| 0 - 1 | Barcelona Sp
66' Martínez, Emmanuel (1994)
|
| |
| 02-Mar-22 21:30
Jorge Luis Hirschi
Ref: Wilton Sampaio
Lm 1: Pires
Lm 2: Boschilia
|
 | Estudiantes de La Plata
Rogel, A 45'
Díaz, Leandro (1992) 84'
| 2 - 0 | Audax Italiano
|
| |
| 03-Mar-22 19:30
Atanasio Girardot
Atte:37204
Ref: Loustau, P
Lm 1: Brailovski
Lm 2: Chade
|
 | Atletico Nacional
Andrade, Andrés 46'
| 1 - 1 | Olimpia
56' Salcedo, Saúl
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