| | | | | |
| 26-Aug-22 19:00
Austin FC Stadium
Atte:20738
Ref:Chilowicz
|
 | Austin FC
Fagúndez, D 32' 
Urruti 47' 
Urruti 51'
Driussi 59'
| 4 - 1 | Los Angeles FC
61' Arango, C
|
| |
| 26-Aug-22 19:00
Providence Park
Atte:25218
Ref:Elfath
|
 | Portland Timbers
Asprilla, D 41' 
Blanco 51'
| 2 - 1 | Seattle Sounders
8' Gómez Andrade
|
| |
| 27-Aug-22 14:30
Allianz Field
Atte:19624
Ref:Mendoza, R
|
 | Minnesota United FC
Picault 79'  og
Amarilla, L 84'
| 2 - 1 | Houston Dynamo
45' Baird, C
|
| |
| 27-Aug-22 18:00
Soldier Field
Atte:13907
Ref:Radchuk
|
 | Chicago Fire
| 0 - 2 |  CF Montréal
19' Koné, Ismael
24' Quioto
|
| |
| 27-Aug-22 19:00
Red Bull Arena
Atte:21374
Ref:Bazakos, F
|
 | New York Red Bulls
Morgan, L 43'
Edelman 53'
Clark, Caden 74'
| 3 - 1 | Inter Miami CF
19' Higuaín
|
| |
| 27-Aug-22 19:00
BC Place
Atte:16351
Ref:Freemon
|
 | Vancouver Whitecaps
| 0 - 3 | Nashville SC
19' Leal, Randall
23' Maher, J
49' Maher, J
 90' McCarty
|
| |
| 27-Aug-22 19:30
West End Stadium
Atte:25037
Ref:Stott, K
|
 | FC Cincinnati
Vázquez, B 36'
Miazga 77'
| 2 - 2 | Columbus Crew
74' Etienne, D
96' Moreira, S
|
| |
| 27-Aug-22 19:30
Subaru Park
Atte:18005
Ref:Chapman
|
 | Philadelphia Union
Gazdag 9'
Gazdag 20'
Carranza, Julián 30'
Gazdag 83'
Burke, Cory 87'
Real 90'
| 6 - 0 | Colorado Rapids
|
| |
| 27-Aug-22 19:30
Children's Mercy Park
Atte:18241
Ref:Gonzalez Jr
|
 | Sporting Kansas City
Sallói 9'
| 1 - 0 | San Jose Earthquakes
|
| |
| 27-Aug-22 20:00
Toyota Stadium
Atte:15573
Ref:Touchan
|
 | FC Dallas
Velasco, Alan 7'
| 1 - 1 | Real Salt Lake
69' Anderson Julio
|
| |
| 27-Aug-22 20:10
Bank of America Stadium
Atte:32495
Ref:Ford, T
|
 | Charlotte FC
| 0 - 2 | Toronto FC
49' Insigne
66' Bernardeschi
|
| |
| 28-Aug-22 16:00
Mercedes-Benz Stadium
Atte:42561
Ref:Saghafi
|
 | Atlanta United FC
Franco, Alan 49'
Martinez, Josef 62'
Sánchez, Juanjo 69'
| 3 - 2 | D.C. United
47' Morrison, R
55' Kamara, O
|
| |
| 28-Aug-22 19:30
Orlando City Stadium
Ref:Penso, C
|
 | Orlando City
Junior Urso 7'
Akindele 96'
| 2 - 1 | New York City FC
53' Moralez, Maxi (1987)
|
| |
| 28-Aug-22 20:00
Gillette Stadium
Atte:21517
Ref:Vazquez
|
 | New England Revolution
Carles Gil 82'
| 1 - 2 | LA Galaxy
4' Aguirre, Daniel
15' Hernández, Javier (1988)
|
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