| Lineups found Starting lineup changes since last game |
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| January 2023 |
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| Coach van Nistelrooy since 01-Jul-22 |
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 27-Aug to 30-Aug Ledezma, R Injury |
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| 27-Aug to 19-Oct de Jong, L Injury |
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| 27-Aug to 13-Nov van Ginkel Injury |
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| 27-Aug to 30-Sep Oppegård Injury |
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| 09-Sep to 11-Sep Hazard, T Thigh Injury |
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| 12-Oct to 13-Nov Saibari Thigh Injury |
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| 12-Oct to 02-Nov Vertessen Muscle Injury |
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| 26-Oct to 13-Nov Peersman, K Injury |
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| 02-Nov to 05-Nov Sangaré, I (1997) Illness |
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| 06-Jan to 06-Feb Boscagli Knee Injury |
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| 06-Jan to 08-Jan van Ginkel Injury |
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| 06-Jan to 16-Jan Peersman, K Back Injury |
| M.4 | 10-Jan | away | Sparta | | 1-2 | 4-3-3 | |
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| February 2023 |
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| 14-Jan to 23-Jan Fofana, F Injury |
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| 14-Jan to 22-Jan Mauro Júnior Injury |
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| 14-Jan to 25-Jan Savinho Injury |
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| 20-Jan to 22-Jan Max, P Illness |
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| 23-Jan to 27-Jan Saibari Injury |
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 27-Jan to 29-Jan Mauro Júnior Red Card |
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| 27-Jan to 29-Jan de Jong, L Head Injury |
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| 27-Jan to 12-Feb Savinho Personal Reasons |
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| 04-Feb to 06-Feb Mauro Júnior Red Card |
| M.5 | 08-Feb | | FC Emmen | | 3-1 | 4-2-3-1 | In:v Aanholt, Veerman, Bakayoko, Til, Out:Max, P, Gutiérr., Madueke, E-Ghazi, |
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| 10-Feb to 04-Mar El-Ghazi Muscle Injury |
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| 10-Feb to 22-Feb Mwene Head Injury |
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| 10-Feb to 12-Feb Obispo Red Card |
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| 14-Feb to 16-Feb Madueke, Noni Inactive |
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| 15-Feb to 06-Mar Savinho Muscle Injury |
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| 18-Feb to 24-Apr Fofana, F Injury |
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| 18-Feb to 20-Feb Gutiérrez, Erick Illness |
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| 18-Feb to 18-Mar Hazard, T Muscle Injury |
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| 18-Feb to 20-Feb Ledezma, R Illness |
| March 2023 |
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| M.6 | 02-Mar | | ADO | | 3-1 | 4-2-3-1 | In:Mwene, F Silva, Out:Teze, X Simons, |
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| April 2023 |
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| 04-Mar to 11-Mar Til Ankle Injury |
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| 06-Mar to 08-Mar Madueke, Noni Inactive |
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| 11-Mar to 13-Mar Benítez, W Knee Injury |
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| 11-Mar to 31-Mar Savinho Personal Reasons |
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| 15-Mar to 17-Mar Vertessen Injury |
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| 31-Mar to 07-Apr Benítez, W Knee Injury |
| M.7 | 04-Apr | away | Spkenburg | | 1-2 | 4-2-3-1 | In:Teze, Gutiérr., X Simons, Out:Mwene, Branthw., F Silva, |
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| 11-Apr to 19-Apr Madueke, Noni Inactive |
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| 15-Apr to 23-Apr Mwene Injury |
| M.8 | 30-Apr | away | Ajax | | 1-1 | 4-4-2 | In:Branthw., Out:Gutiérr., |
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| Color References: GK, DF, DM, MF, FW , Unknown Pos |