| Lineups found Starting lineup changes since last game |
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| December 2021 |
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| Coach Ancelotti since 02-Jun-21 |
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 11-Dec to 13-Dec Dani Ceballos Ankle Injury |
| January 2022 |
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| 18-Dec to 13-Feb Mariano, D Muscle Injury |
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| 18-Dec to 24-Jan Carvajal, D Illness |
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| 18-Dec to 24-Jan Marco Asensio Muscle Injury |
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| 18-Dec to 09-Jan Bale Back Injury |
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| 18-Dec to 23-Dec Isco Illness |
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| 18-Dec to 23-Dec Lunin, Andriy Illness |
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| 18-Dec to 23-Dec Marcelo Illness |
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| 18-Dec to 23-Dec Modrić Illness |
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| 18-Dec to 23-Dec Rodrygo, Goes Illness |
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| 21-Dec to 23-Dec Alaba Illness |
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 21-Dec to 23-Dec Casemiro Yellow Cards |
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| 01-Jan to 09-Jan Jović, L Illness |
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| 01-Jan to 03-Jan Camavinga Yellow Cards |
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| 01-Jan to 03-Jan Vinícius Jr Illness |
| M.3 | 05-Jan | away | Alcoyano | | 1-3 | lineup not confirmed |
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| M.4 | 20-Jan | away | Elche | | 1-2 | 4-3-3 | |
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| February 2022 |
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| 02-Feb to 13-Feb Benzema thigh injury |
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| 02-Feb to 04-Feb Marcelo red card |
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| 02-Feb to 13-Feb Mendy, Ferland muscle injury |
| M.5 | 03-Feb | away | Athletic | | 1-0 | 4-3-3 | In:Courtois, É Militão, Modrić, Casemiro, M Asensio, Out:Lunin, Marcelo, Valverde, Camavin., Jović, |
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| 05-Feb to 07-Feb Vinícius Jr Yellow Cards |
| March 2022 |
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| 11-Feb to 13-Feb Hazard Injury |
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| 25-Feb to 27-Feb Alaba Muscle Injury |
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| 25-Feb to 27-Feb Bale Muscle Injury |
| April 2022 |
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| 04-Mar to 06-Mar Kroos Muscle Injury |
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| 04-Mar to 06-Mar Valverde, Fede Illness |
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| 08-Mar to 10-Mar Casemiro Yellow Cards |
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| 08-Mar to 10-Mar Mendy, Ferland Yellow Cards |
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| 19-Mar to 21-Mar Benzema Muscle Injury |
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| 19-Mar to 21-Mar Mendy, Ferland Muscle Injury |
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| 01-Apr to 13-Apr Isco Injury |
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| 08-Apr to 21-Apr Mendy, Ferland Injury |
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| 11-Apr to 13-Apr Éder Militão Yellow Cards |
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| 11-Apr to 21-Apr Vallejo, J Illness |
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| 16-Apr to 18-Apr Casemiro Yellow Cards |
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| 16-Apr to 18-Apr Dani Ceballos Illness |
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| 16-Apr to 21-Apr Marcelo Muscle Injury |
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 20-Apr to 20-Apr Rodrygo, Goes 100th game with Real Madrid |
| Color References: GK, DF, DM, MF, FW , Unknown Pos |